Estimation of renin and D-dimer levels in women with polycystic ovary disease with or without coronavirus infection

Shaimaa Ali; Fayhaa Khaleel; Farah Ali

doi:10.47419/bjbabs.v3i04.151

Authors

Shaimaa E. Ali Department of Chemistry, College of Sciences for Women, University of Baghdad, Baghdad, Iraq
Fayhaa M. Khaleel Department of Chemistry, College of Sciences for Women, University of Baghdad, Baghdad, Iraq
Farah E. Ali Kamal Al-Samarrai Hospital, Iraqi Ministry of Health, Baghdad, Iraq

DOI:

https://doi.org/10.47419/bjbabs.v3i04.151

Keywords:

COVID-19, follicle-stimulating hormone, FSH, PCOS

Abstract

Background and objective: Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder among women of childbearing age. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to determine the levels of renin, d-dimer, and some relevant biomarkers in patients with PCOS (with and without COVID-19) compared with non-PCOS patients (with and without COVID-19).

Methods: This cross-sectional study included 120 women [80 PCOS women (40 with COVID-19 and 40 without COVID-19) and 40 non-PCOS women (20 with COVID-19 and 20 without)] with age range of 15–40 years old. Blood samples were collected from participants, and biochemical assays were carried out. Renin and d-dimer levels were determined using the enzyme-linked-immunosorbent-assay (ELISA), lipid-profile and fasting blood glucose concentrations were assessed by using the colorimetric methods, and hormones were evaluated by VIDAS.

Results: Renin and d-dimer levels were found to be significantly higher in PCOS-women groups compared to non-PCOS group. In addition, the results showed that hormones, fasting blood glucose, and lipid-profile are significantly increased in PCOS patients compared to non-PCOS women, while high-density-lipoprotein and follicle-stimulating-hormone levels were low when comparing PCOS patients with non-PCOS ones. The results also showed that a highly significant increase in renin and d-dimer levels can be detected in PCOS patients with COVID-19.

Conclusions: In the present study, we found there is a possible relationship between renin and d-dimer in PCOS patients who are also COVID-19 infected.

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