Pharmacological and therapeutic potential of ginger in the management of neurodegenerative disorders
DOI:
https://doi.org/10.47419/bjbabs.v4i04.169Keywords:
ginger, neurodegenerative diseases, gingerol, antioxidant, anti-inflammationAbstract
Secondary metabolites in ginger include 6-gingerol, 6-shogaol, 10-gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6- gingerol, 3,5-diacetoxy-6-gingerdiol, and 12-gingerol, all of which account for ginger's well-known pharmacological actions. Six-shogaol and six-gingerol are two of the most important active ingredients. There is experimental evidence to back ginger's medicinal properties, such as its antioxidant and anti-inflammatory activities. In contrast, ginger's purported neuroprotective advantage is a niche bioactivity with limited study. Increasing oxidative stress, neuroinflammation, and protein misfolding are common neuropathological characteristics of neurodegenerative disorders (NDs), which have become more common as life expectancy has increased. Ginger may be a potential for treating NDs because its phytochemicals target distinct ligand sites, as shown by their structure-activity relationships. Bioactive substances found there may help relieve neurological problems and pathological disorders by affecting markers which express apoptosis or sustenance. The cognitive-enhancing properties of ginger may be explained by its effects on the monoamine and cholinergic systems in various brain areas. In addition, ginger reduces the generation of inflammatory associated components. The current review intends to describe the impacts of ginger in the management of significant neurological conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
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