The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics

Authors

  • Waleed Mohammed Department of Basic Science, College of Dentistry, University of Anbar, Anbar, Iraq
  • Fatimah Abdulazeez Awad Department of Basic Science, College of Dentistry , University Of Anbar , Ramadi, Iraq
  • Thana I. Mustafa Department of Basic Science, College of Dentistry , University Of Anbar , Ramadi, Iraq

DOI:

https://doi.org/10.47419/bjbabs.v4i04.211

Keywords:

mechanisms of antibiotic resistance, Antibiotic-Resistant Strains, k.pneumoniae, Molecular characteristics, Genetics, Gene transfer mechanisms

Abstract

Klebsiella pneumoniae is a significant pathogen causing various infections, and antibiotic-resistant strains of K.pneumoniae are becoming more prevalent. Molecular studies reveal the genetic mechanisms underlying antibiotic resistance, such as resistance genes on plasmids that can easily spread between bacteria. Knowledge of the molecular characteristics of antibiotic-resistant strains is crucial to develop effective strategies against their spread. The bacteria can easy colonizes the human gut and  can also cause a range of infections, including pneumonia, urinary tract infections, and bloodstream infections.

The emergence of antibiotic-resistant strains of K.pneumoniae has become a major public health concern, as these strains are associated with increased morbidity and mortality rates, longer hospital stays, and higher healthcare costs. Antibiotic resistance in K.pneumoniae involves several mechanisms, including beta-lactamase production, changes in outer membrane porins, and the uptake of resistance genes via horizontal gene transfer. 

The genetics and genomics of K.pneumoniae are also of significant interest, as they provide insights into the diversity of strains and their pathogenic potential. Genome sequencing has revealed the existence of distinct lineages of K. pneumoniae, each with unique virulence factors and antimicrobial resistance profiles. 

To summarize, K.pneumoniae is a critical pathogen that poses a substantial global public health threat. The rising prevalence of antibiotic-resistant strains underscores the pressing need for innovative approaches to prevent and treat K.pneumoniae infections. Comprehensive knowledge of the molecular mechanisms of virulence, pathogenicity, and antibiotic resistance, as well as the genetic diversity of K. pneumoniae, will be essential in developing effective strategies to combat this pathogen.

 

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The Importance of Klebsiella pneumonia as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristic

Published

23-12-2023

How to Cite

The Importance of Klebsiella pneumoniae as a Pathogen and the Increasing Prevalence of Antibiotic-Resistant Strains and Molecular Characteristics. (2023). Baghdad Journal of Biochemistry and Applied Biological Sciences, 4(4), 180-203. https://doi.org/10.47419/bjbabs.v4i04.211

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