Herbal medicine as an alternative method to treat and prevent COVID-19


  • Ahmed N. Al-Doori Biomedical Engineering and Mechanics, College of Engineering, Virginia Tech University, Blacksburg, VA 24061, United States
  • Dina S. Ahmed Department of Medical Instrumentation Engineering, Al‐Mansour University College, Baghdad 64021, Iraq
  • Mohammed Kadhom Department of Renewable Energy, College of Energy and Environmental Sciences, Alkarkh University of Science, Baghdad, Iraq
  • Emad A. Yousif Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq




COVID19, medicinal plants, nature herbal medicine, plants extract, traditional Chinese medicine, treatment methods


The current outbreak of serious respiratory syndrome (COVID-19) has resulted from a novel coronavirus (SARS-CoV-2) infection. This infectious disease was classified as a pandemic by the World Health Organization (WHO) because it threatens public health and life worldwide. Recently, restrictions in many countries are applied to detect the infected individuals, isolate them, and attempt to find appropriate treatments that can help decrease the disease’s severe symptoms. Regardless of the conducted efforts, the number of reported cases of coronavirus infections is still growing up. Yet, no medication or vaccine was approved to prevent and treat people from this coronavirus, though many research and medication companies are still developing medicines. This review aims to summarize the possible herbs and plants as natural herbal medicine along with western medicine, which could assist treat or protect people from COVID-19. Compounds of andrographolide, quercetin, baicalin, curcumin, glycyrrhizic acid, emodin, patchouli alcohol, luteolin, and myricetin are found in different plants and were found to be good health remedies. Understanding the infection rules, clarifying the pathogenic mechanisms, and detecting the appropriate medication treatment could improve the development of the essential treatment and prevention methods. Since the finally-approved drug for this virus is still absent, and a sharp increase in infection numbers is taking place, it becomes urgent to present possible alternatives, such as the Chinese herbal medicines, in an attempt to cure SARS-CoV-2 infection.


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A Hadi et al. “A review on COVID-19: Origin, spread, symptoms, treatment, and prevention”. Biointerface Res Appl Chem 10(6) (2020), pp. 7234–7242. DOI: 10.33263/BRIAC106.72347242. DOI: https://doi.org/10.33263/BRIAC106.72347242

A Soleymani and M H Shahrajabian. “Response of different cultivars of fennel (Foeniculum vulgare) to irrigation and planting dates in Isfahan”. Res Crops 13 (2012), pp. 656–660.

Akerele Olayiwola. “Medicinal plants and primary health care: an agenda for action”. East Mediterr Region Drugs Digest 8(2) (1991), pp. 11–25.

Ángela Rojas et al. “Effect of quercetin on hepatitis C virus life cycle: From viral to host targets”. Sci Rep 6(1) (2016), p. 31777. DOI: 10.1038/srep31777. DOI: https://doi.org/10.1038/srep31777

Ashok Kumar Pandurangan and Norhaizan Mohd Esa. “Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: A review”. Asian Pac J Cancer Prev 15(14) (2014), pp. 5501–5508. DOI: 10.7314/apjcp.2014.15.14.5501. DOI: https://doi.org/10.7314/APJCP.2014.15.14.5501

Atchara Paemanee et al. “A proteomic analysis of the anti-dengue virus activity of andrographolide”. Biomed Pharmacother 109 (2019), pp. 322–332. DOI: 10.1016/j.biopha.2018.10.054. DOI: https://doi.org/10.1016/j.biopha.2018.10.054

B Atala et al. “Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies”. Sci Rep 11(2043) (2021). DOI: 10.1038/s41598-021-81462-7. DOI: https://doi.org/10.1038/s41598-021-81462-7

Chenguang Yao et al. “Inhibition of enterovirus 71 replication and viral 3C protease by quercetin”. Virol J 15(1) (2018), p. 116. DOI: 10.1186/s12985-018-1023-6. DOI: https://doi.org/10.1186/s12985-018-1023-6

D Liu et al. “Clinical observation on the preventive effect of kangdu bufei decoction on acute severe respiratory syndrome”. Chin J Integr Trad West Med 24 (2004), pp. 685–688.

D Wang, H Guo, and J Chang. “Andrographolide prevents EV-D68 replication by inhibiting the acidification of virus-containing endocytic vesicles”. Front Microbiol 9 (2018), p. 2407. DOI: 10.3389/fmicb.2018.02407. DOI: https://doi.org/10.3389/fmicb.2018.02407

Deepak Semwal et al. “Myricetin: A dietary molecule with diverse biological activities”. Nutrients 8(2) (2016), p. 90. DOI: 10.3390/nu8020090. DOI: https://doi.org/10.3390/nu8020090

Digambara Patra and Christelle Barakat. “Synchronous fluorescence spectroscopic study of solvatochromic curcumin dye”. Spectrochim Acta A Mol Biomol Spectrosc 79(5) (2011), pp. 1034–1041. DOI: 10.1016/j.saa.2011.04.016. DOI: https://doi.org/10.1016/j.saa.2011.04.016

F Chen et al. “In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds”. J Clin Virol 31(1) (2004), pp. 69–75. DOI: 10.1016/j.jcv.2004.03.003. DOI: https://doi.org/10.1016/j.jcv.2004.03.003

G D'andrea. “Quercetin: A flavonol with multifaceted therapeutic applications?” Fitoterapia 106 (2015), pp. 256–71. DOI: 10.1016/j.fitote.2015.09.018. DOI: https://doi.org/10.1016/j.fitote.2015.09.018

G Hu et al. “Availability, pharmaceutics, security, pharmacokinetics, and pharmacological activities of patchouli alcohol”. Evid Based Complement Alternat Med (2017), p. 4850612. DOI: 10.1155/2017/4850612. DOI: https://doi.org/10.1155/2017/4850612

Gail B. Mahady. “Global harmonization of herbal health claims”. J Nutr 131(3s) (2001), 1120S–1123S. DOI: 10.1093/jn/131.3.1120s. DOI: https://doi.org/10.1093/jn/131.3.1120S

Gerold Hoever et al. “Antiviral activity of glycyrrhizic acid derivatives against SARS−coronavirus”. J Med Chem 48(4) (2005), pp. 1256–1259. DOI: 10.1021/jm0493008. DOI: https://doi.org/10.1021/jm0493008

H Du et al. “Antiviral effects and mechanisms of Yinhuapinggan granule against H1N1 influenza virus infection in RAW264.7 cells”. Inflammopharmacology 26(6) (2018), pp. 1455–67. DOI: 10.1007/s10787-018-0457-1. DOI: https://doi.org/10.1007/s10787-018-0457-1

H Lili et al. “Analysis on the application of Traditional Chinese Medicine in the treatment of COVID-19 by suppressing cytokine storm”. Chin Trad Herb Drug (2020).

H Pilcher. “Liquorice may tackle SARS”. Nature (2003). DOI: 10.1038/news030609-16. DOI: https://doi.org/10.1038/news030609-16

H S Chen, S H Qi, and J G Shen. “One-compound-multi-target: Combination prospect of natural compounds with thrombolytic therapy in acute ischemic stroke”. Curr Neuropharmacol 15 (2017), pp. 134–156. DOI: 10.2174/1570159x14666160620102055. DOI: https://doi.org/10.2174/1570159X14666160620102055

Hai-Tao Zhang et al. “Evaluation of the adjuvant efficacy of natural herbal medicine on COVID-19: A retrospective matched case-control study”. Am J Chinese Med 48(04) (2020), pp. 779–792. URL: https://dx.doi.org/10.1142/s0192415x20500391. DOI: https://doi.org/10.1142/S0192415X20500391

Hongzhou Lu, Charles W. Stratton, and Yi-Wei Tang. “Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle”. J Med Virol 92(4) (2020), pp. 401–402. DOI: 10.1002/jmv.25678. DOI: https://doi.org/10.1002/jmv.25678

J Cinatl et al. “Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus”. Lancet 361(9374) (2003), pp. 2045–2046. DOI: 10.1016/s0140-6736(03)13615-x. DOI: https://doi.org/10.1016/S0140-6736(03)13615-X

J F Chan et al. “A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster”. Lancet 395 (2020), pp. 514–523. DOI: 10.1016/S0140-6736(20)30154-9. DOI: https://doi.org/10.1016/S0140-6736(20)30154-9

Jason Kindrachuk et al. “Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for middle east respiratory syndrome coronavirus infection as identified by temporal kinome analysis”. Antimicrob Agents Chemother 59(2) (2015), pp. 1088–1099. DOI: 10.1128/aac.03659-14. DOI: https://doi.org/10.1128/AAC.03659-14

K C Wang et al. “ Antiviral effect of cimicifugin from Cimicifuga foetida against human respiratory syncytial virus”. Am J Chin Med 40(5) (2012), pp. 1033–1045. DOI: 10.1142/S0192415X12500760. DOI: https://doi.org/10.1142/S0192415X12500760

K Kitazato, Y Wang, and N Kobayashi. “Viral infectious disease and natural products with antiviral activity”. Drug Discov Ther 1(1) (2007), pp. 14–22.

L - T Lin, W - C Hsu, and C - C Lin. “Antiviral natural products and herbal medicines”. J Trad Complemen Med 4 (2014), pp. 24–35. DOI: 10.4103/2225-4110.124335. DOI: https://doi.org/10.4103/2225-4110.124335

M H Shahrajabian, W Sun, and Q Cheng. “A review of astragalus species as foodstuffs, dietary supplements, a traditional Chinese medicine and a part of modern pharmaceutical science”. Appl Ecol Environ Res 17(6) (2019), pp. 13371–13382. DOI: 10.15666/aeer/1706_1337113382. DOI: https://doi.org/10.15666/aeer/1706_1337113382

M H Shahrajabian, W Sun, and Q Cheng. “Chinese star anise and anise, magic herbs intraditional Chinese medicine and modern pharmaceutical science”. Asian J Med Biol Res 5(3) (2019), pp. 162–179. DOI: 10.3329/ajmbr.v5i3.43584. DOI: https://doi.org/10.3329/ajmbr.v5i3.43584

M Ishfaq et al. “Baicalin ameliorates oxidative stress and apoptosis by restoring mitochondrial dynamics in the spleen of chickens via the opposite modulation of NF-κB and Nrf2/HO-1 signaling pathway during Mycoplasma gallisepticum infection”. Poult Sci 98 (2019), pp. 6296–6310. DOI: 10.3382/ps/pez406. DOI: https://doi.org/10.3382/ps/pez406

M S Yu, J Lee, and J M Lee. “Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13”. Bioorg Med Chem Lett 22(12) (2012), pp. 4049–4054. DOI: 10.1016/j.bmcl.2012.04.081. DOI: https://doi.org/10.1016/j.bmcl.2012.04.081

M Zhang, X Liu, and L He. “Effect of integrated traditional Chinese and Western medicine on SARS: A review of clinical evidence”. World J Gastroenterol 10(23) (2004), pp. 3500–3505. DOI: 10.3748/wjg.v10.i23.3500. DOI: https://doi.org/10.3748/wjg.v10.i23.3500

Martins Ekor. “The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety”. Front Pharmacol 4 (2014), p. 177. DOI: 10.3389/fphar.2013.00177. URL: https://dx.doi.org/10.3389/fphar.2013.00177. DOI: https://doi.org/10.3389/fphar.2013.00177

Mayur M. Uttekar et al. “Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding”. Eur J Med Chem 56 (2012), pp. 368–374. DOI: 10.1016/j.ejmech.2012.07.030. DOI: https://doi.org/10.1016/j.ejmech.2012.07.030

Michal Heger et al. “The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer”. Pharmacol Rev 66(1) (2014), pp. 222–307. DOI: 10.1124/pr.110.004044. DOI: https://doi.org/10.1124/pr.110.004044

Mohamed A. Farag and Ludger A. Wessjohann. “Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics”. J Food Sci 77(11) (2012), pp. C1179–C1184. DOI: 10.1111/j.1750-3841.2012.02927.x. DOI: https://doi.org/10.1111/j.1750-3841.2012.02927.x

Muhammad Faisal Manzoor et al. “Novel extraction techniques and pharmaceutical activities of luteolin and its derivatives”. J Food Biochem 43(9) (2019), e12974. DOI: 10.1111/jfbc.12974. DOI: https://doi.org/10.1111/jfbc.12974

N Zhu et al. “A novel coronavirus from patients with pneumonia in China, 2019”. N Engl J Med 382 (2020), pp. 727–733. DOI: 10.1056/NEJMoa2001017. DOI: https://doi.org/10.1056/NEJMoa2001017

One patient with 2019-nCoV pneumonia was discharged today in Beijing, with a total of two discharged. 2020. URL: http://wjw.beijing.gov.cn/xwzx_20031/wnxw/202001/t20200125_1621329.html.

P Yang et al. “Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China”. medRxiv (2020). DOI: 10.1101/2020.02.28.20028068. DOI: https://doi.org/10.1101/2020.02.28.20028068

Patcharee Panraksa et al. “Activity of andrographolide against dengue virus”. Antiviral Res 139 (2017), pp. 69–78. DOI: 10.1016/j.antiviral.2016.12.014. DOI: https://doi.org/10.1016/j.antiviral.2016.12.014

Phitchayapak Wintachai et al. “Activity of andrographolide against chikungunya virus infection”. Sci Rep 5(1) (2015), p. 14179. DOI: 10.1038/srep14179. URL: https://dx.doi.org/10.1038/srep14179. DOI: https://doi.org/10.1038/srep14179

Q Ma et al. “San Wu Huangqin decoction, a Chinese herbal formula, inhibits influenza a/PR/8/34 (H1N1) virus infection in vitro and in vivo”. Viruses 10(3) (2018), p. 117. DOI: 10.3390/v10030117. DOI: https://doi.org/10.3390/v10030117

R Alsayed et al. “An epidemiological characteristic of the COVID-19 among children”. Lett Appl NanoBioScience 9(3) (2020), pp. 1156–1164. DOI: 10.33263/LIANBS93.11561164. DOI: https://doi.org/10.33263/LIANBS93.11561164

Rajesh Kumar Ganjhu et al. “Herbal plants and plant preparations as remedial approach for viral diseases”. Virusdisease 26(4) (2015), pp. 225–236. DOI: 10.1007/s13337-015-0276-6. DOI: https://doi.org/10.1007/s13337-015-0276-6

Sukanth Kumar Enmozhi et al. “Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach”. J Biomol Struct Dyn (2020), pp. 1–7. DOI: 10.1080/07391102.2020.1760136. DOI: https://doi.org/10.1080/07391102.2020.1760136

Swati Gupta, K. P. Mishra, and Lilly Ganju. “Broad-spectrum antiviral properties of andrographolide”. Arch Virol 162(3) (2017), pp. 611–623. DOI: 10.1007/s00705-016-3166-3. DOI: https://doi.org/10.1007/s00705-016-3166-3

T T Nguyen et al. “Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris”. Biotechnol Lett 34 (2012), pp. 831–838. DOI: 10.1007/s10529-011-0845-8. DOI: https://doi.org/10.1007/s10529-011-0845-8

The General Office of the National Health and Health Commission of China, Office of the State Administration of Traditional Chinese Medicine. “Pneumonitis Diagnosis and Treatment Program for New Coronavirus Infection ”. In: 2020.

The National Health Commission and the National Administration of Traditional Chinese Medicine of the People’s Republic of China: Guidance for Corona Virus Disease 2019: Prevention, Control, Diagnosis and Management. Tentative 4th Edition. 2020.

Tin-Yun Ho et al. “Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction”. Antivir Res 74 (2007), pp. 92–101. DOI: 10.1016/j.antiviral.2006.04.014. DOI: https://doi.org/10.1016/j.antiviral.2006.04.014

V. Kishore et al. “Multi-targeting andrographolide and its natural analogs as potential therapeutic agents”. Curr Top Med Chem 17(8) (2017), pp. 845–857. DOI: 10.2174/1568026616666160927150452. DOI: https://doi.org/10.2174/1568026616666160927150452

W Sun, M H Shahrajabian, and Q Cheng. “Anise (Pimpinella anisum l.), a dominant spice and traditional medicinal herb for both food and medicinal purposes”. Cogent Biol 5(1673688) (2019), pp. 1–25. DOI: 10.1080/23312025.2019.1673688. DOI: https://doi.org/10.1080/23312025.2019.1673688

W Sun, M H Shahrajabian, and Q Cheng. “The insight and survey on medicinal properties and nutritive components of shallot”. J Med Plant Res 13(18) (2009), pp. 452–457. DOI: 10.5897/JMPR2019.6836. DOI: https://doi.org/10.5897/JMPR2019.6836

W Wu et al. “Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry”. Viruses 8 (2015). DOI: 10.3390/v8010006. DOI: https://doi.org/10.3390/v8010006

WHO. WHO Director-General’s remarks at the media briefing on 2019-nCoV. Feb. 11, 2020. URL: https://www.who.int/dg/speeches/detail/who-director-general-s-remarks- at-the-media-briefing-on- (visited on 03/27/2020).

X Dong et al. “Emodin: A review of its pharmacology, toxicity and pharmacokinetics”. Phytother Res 30 (2016), pp. 1207–1218. DOI: 10.1002/ptr.5631. DOI: https://doi.org/10.1002/ptr.5631

X Tong et al. “TCM treatment of infectious atypical pneumonia-a report of 16 cases”. Journal of Traditional Chinese Medicine 24(4) (2004), pp. 266–269.

X Yang et al. “Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study”. Lancet Respir Med 8(5) (2020), pp. 475–481. DOI: 10.1016/S2213-2600(20)30079-5. DOI: https://doi.org/10.1016/S2213-2600(20)30079-5

Y B Ryu et al. “Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition”. Bioorg Med Chem 18 (2010), pp. 7940–7947. DOI: 10.1016/j.bmc.2010.09.035. DOI: https://doi.org/10.1016/j.bmc.2010.09.035

Y Ding et al. “Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-kappaB and JAK-STAT signaling pathway”. Microbes Infect 19 (2017), pp. 605–615. DOI: 10.1016/j.micinf.2017.08.009. DOI: https://doi.org/10.1016/j.micinf.2017.08.009

Y Ding et al. “The Chinese prescription lianhuaqingwen capsule exerts antiinfluenza activity through the inhibition of viral propagation and impacts immune function”. Bmc Complementary & Alternative Medicine 17(1) (2017), p. 130. DOI: 10.1186/s12906-017-1585-7. DOI: https://doi.org/10.1186/s12906-017-1585-7

Y Li et al. “Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis”. Syst Rev 9 (2020), p. 75. DOI: 10.1186/s13643-020-01343-4. DOI: https://doi.org/10.1186/s13643-020-01343-4

Y Yang et al. “Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): A review and perspective”. Int J Biol Sci 16(10) (2020), pp. 1708–1717. DOI: 10.7150/ijbs.45538. DOI: https://doi.org/10.7150/ijbs.45538

Y. F. Deng et al. “Inhibitory activities of baicalin against renin and angiotensin-converting enzyme”. Pharm Biol 50(4) (2012), pp. 401–406. DOI: 10.3109/13880209.2011.608076. DOI: https://doi.org/10.3109/13880209.2011.608076

Yao Li et al. “Quercetin, inflammation and immunity”. Nutrients 8(3) (2016), p. 167. DOI: 10.3390/nu8030167. DOI: https://doi.org/10.3390/nu8030167



How to Cite

Herbal medicine as an alternative method to treat and prevent COVID-19. (2021). Baghdad Journal of Biochemistry and Applied Biological Sciences, 2(01), 1-20. https://doi.org/10.47419/bjbabs.v2i01.25