Serum vitamin D3 levels in pregnant women with preeclampsia at third trimester of pregnancy
Keywords:early-onset preeclampsia, late-onset preeclampsia, pregnancy, third trimester, vitamin D
Background: Preeclampsia (PE) is a pregnancy-specific condition, characterized by high blood pressure and proteinuria after 20 weeks of gestation. One of the hypotheses concerning the etiology of PE is vitamin D3 deficiency during pregnancy. Vitamin D3 is especially important during pregnancy as low maternal vitamin D3 stores may contribute to problems like low birth weight as well as an increased risk of maternal comorbidities.
Objectives: To evaluate serum vitamin D3 levels and how they can be affected by the severity of PE at the third trimester of pregnancy.
Methods: This case-control study included a total of 71 pregnant women at the third trimester of pregnancy (41 with PE and 30 without PE as controls). Vitamin D3 serum level was measured by enzyme-linked immune-sorbent assay (ELISA).
Results: The study’s findings showed no significant difference in serum vitamin D3 level (p>0.05) between controls (14.41±1.41ng/ml) and PE patients (14.32±1.00). As well, subgroup analysis revealed non-considerable changes between mild PE cases (15.92±1.73 ng/ml) and severe ones (13.07±1.09 ng/ml).
Conclusions: PE and its severity may have no significant effect on serum vitamin D3 levels of pregnant women at the third trimester of pregnancy.
Adi Sharabi-Nov et al. “Maternal Serum Inhibin-A Augments the Value of Maternal Serum PlGF and of sFlt-1/PlGF Ratio in the Prediction of Preeclampsia and/or FGR Near Delivery—A Secondary Analysis”. Reprod Med 2(1) (2021), pp. 35–49. DOI: 10.3390/reprodmed2010005.
Aleksandar Radujkovic et al. “Vitamin D Deficiency and Outcome of COVID-19 Patients”. Nutrients 12(9) (2020), pp. 2757–2757. DOI: 10.3390/nu12092757.
Ali Abdulhakeem Hassan Albakaa, Amer Muhssen Naser, and Ali Riyad Saleim. “Determination of Pregnant women Knowledge toward Risk Factors of Vitamin D Deficiency and Measuring Level During Pregnancy in Al- Nasiriyah City”. Ann Trop Med Public Health 23(13) (2020). DOI: 10.36295/asro.2020.231333.
Bernat Serra et al. “A new model for screening for early-onset preeclampsia”. Am J Obstet Gynecol 222(6) (2020), 608.e1–608.e18. DOI: 10.1016/j.ajog.2020.01.020.
Clare B. Kelly et al. “Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes”. Nutrients 12(7) (2020), pp. 2048–2048. DOI: 10.3390/nu12072048.
H Sima et al. “The Relationship of Vitamin D and Calcium level with Preeclampsia Severity: A Case- control Study”. Int J Pediatr 5(6) (2017), pp. 42–42.
Hetti von Hellens, Leea Keski-Nisula, and Heidi Sahlman. “Increased risk of preeclampsia after use of paracetamol during pregnancy – causal or coincidence?” BMC Pregnancy Childbirth 21(1) (2021), pp. 24–24. DOI: 10.1186/s12884-020-03490-x.
Maryam Ebadi and Aldo J. Montano-Loza. “Perspective: improving vitamin D status in the management of COVID-19”. European Journal of Clinical Nutrition 74(6) (2020), pp. 856–859. DOI: 10.1038/s41430-020-0661-0.
Mattia Bellan et al. “Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases”. Nutrients 12(3) (2020), pp. 789–789. DOI: 10.3390/nu12030789.
N A Nasser et al. “Correlation between Serum & Urinary Placental Protein (Pp13) in Pre-eclamptic Women at their Third Trimester”. Indian J Forensic Med Toxicol (2020).
Nesreen A. Nasser et al. “Serum placental growth factor (PLGF) and soluble fms-like tyrosine kinase- 1(sFLT-1) in preeclamptic women at their third trimester of pregnancy”. Baghdad J Biochem Appl Biol Sci 1(01) (2020), pp. 39–45. DOI: 10.47419/bjbabs.v1i01.30.
Nesreen Ahmed Nasser et al. “The association between urinary placental protein 13 and soluble fms- like tyrosine kinase-1 in preeclamptic women in the third trimester of pregnancy”. Baghdad J Biochem Appl Biol Sci 1(01) (2020), pp. 46–51. DOI: 10.47419/bjbabs.v1i01.31.
Roxana Bohiltea et al. “Inherited thrombophilia is significantly associated with severe preeclampsia”. Experimental and Therapeutic Medicine 21(3) (2021), pp. 261–261. DOI: 10.3892/etm.2021.9691.
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Copyright (c) 2021 Anas H. Sadek, Rayah S. Baban, May F. Al-Habib, Enas A. Khazaali
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